InnateDB Protein
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IDBP-246631.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPP1R12B
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Protein Name
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protein phosphatase 1, regulatory subunit 12B
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Synonyms
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MYPT2; PP1bp55;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000375821
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InnateDB Gene
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IDBG-105846 (PPP1R12B)
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Protein Structure
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Function |
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269PubMed:11067852, ECO:0000269PubMed:9570949}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12923170}. Note=Along actomyosin filaments and stress fibers.
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Disease Associations |
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Tissue Specificity |
Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific. {ECO:0000269PubMed:11067852, ECO:0000269PubMed:9570949}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008047
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enzyme activator activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O60237
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PhosphoSite |
PhosphoSite-O60237
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TrEMBL |
E1CKY7
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UniProt Splice Variant |
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Entrez Gene |
4660
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UniGene |
Hs.707749
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RefSeq |
NP_001184060
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HUGO |
HGNC:7619
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OMIM |
603768
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CCDS |
CCDS73005
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HPRD |
04794
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IMGT |
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EMBL |
AB003062
AB050641
AB050642
AB588820
AC099336
AF324888
AF324889
AF324890
AF324891
AF324892
AL356953
AL589762
BC034430
BC110907
BC144699
CH471067
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GenPept |
AAH34430
AAI10908
AAI44700
AAK00336
AAK00337
BAA28376
BAB17610
BAB17611
BAJ22080
CAH73374
CAH73375
CAI15934
CAI15935
EAW91418
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