InnateDB Protein
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IDBP-246696.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IL24
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Protein Name
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interleukin 24
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Synonyms
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C49A; FISP; IL10B; MDA7; MOB5; ST16;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000375795
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InnateDB Gene
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IDBG-106283 (IL24)
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Protein Structure
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|
Function |
Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.
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Subcellular Localization |
Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Up-regulated in melanoma cells induced to terminally differentiate.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
|
Protein-Protein |
8
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
1
[view]
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006915
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apoptotic process
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GO:0008284
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positive regulation of cell proliferation
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GO:0008285
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negative regulation of cell proliferation
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GO:0030336
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negative regulation of cell migration
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GO:0033136
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serine phosphorylation of STAT3 protein
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GO:0042060
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wound healing
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GO:0042517
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positive regulation of tyrosine phosphorylation of Stat3 protein
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GO:0043065
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positive regulation of apoptotic process
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GO:0043066
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negative regulation of apoptotic process
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GO:0043154
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negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0043280
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positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0071222
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cellular response to lipopolysaccharide
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GO:0071353
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cellular response to interleukin-4
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Cellular Component |
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PDB ID |
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InterPro |
IPR009079
Four-helical cytokine-like, core
IPR020444
Interleukin-24
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PFAM |
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PRINTS |
PR01937
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13007
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PhosphoSite |
PhosphoSite-Q13007
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11009
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UniGene |
Hs.741469
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RefSeq |
NP_001172085
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HUGO |
HGNC:11346
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OMIM |
604136
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CCDS |
CCDS53465
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HPRD |
04995
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IMGT |
|
EMBL |
AC098935
AF235005
AF276916
AY062931
AY237723
AY641441
BC009681
BT007156
U16261
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GenPept |
AAA91780
AAG41401
AAH09681
AAK52589
AAL34146
AAO67513
AAP35820
AAV52801
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