InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIST3H2BB

Summary

InnateDB Protein

IDBP-246830.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIST3H2BB

Protein Name

histone cluster 3, H2bb

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000375736

InnateDB Gene

IDBG-115825 (HIST3H2BB)

Protein Structure

UniProt Annotation

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002227	innate immune response in mucosa
GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0019731	antibacterial humoral response
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0000786	nucleosome
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0070062	extracellular vesicular exosome