InnateDB Protein
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IDBP-246954.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KLK11
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Protein Name
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kallikrein-related peptidase 11
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Synonyms
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PRSS20; TLSP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000375680
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InnateDB Gene
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IDBG-65474 (KLK11)
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Protein Structure
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Function |
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. {ECO:0000269PubMed:10872828, ECO:0000269PubMed:16467084}.
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Subcellular Localization |
Isoform 1: Secreted.Isoform 2: Golgi apparatus.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level). {ECO:0000269PubMed:10872828, ECO:0000269PubMed:16467084}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001254
Peptidase S1
IPR001314
Peptidase S1A, chymotrypsin-type
IPR009003
Trypsin-like cysteine/serine peptidase domain
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PFAM |
PF00089
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PRINTS |
PR00722
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PIRSF |
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SMART |
SM00020
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBX7
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PhosphoSite |
PhosphoSite-Q9UBX7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11012
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UniGene |
Hs.57771
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RefSeq |
NP_001161077
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HUGO |
HGNC:6359
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OMIM |
604434
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CCDS |
CCDS54297
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HPRD |
05114
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IMGT |
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EMBL |
AB012917
AB013730
AB041036
AB078780
AB259014
AB261897
AC011473
AF164623
AF243527
AY359014
BC022068
CH471135
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GenPept |
AAD47815
AAG23257
AAG33364
AAH22068
AAQ89373
BAA33404
BAA88713
BAA96797
BAC54105
BAE95335
BAF02733
EAW71971
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