Version 5.4
Homo sapiens Protein: LRRFIP2
Summary
InnateDB Protein IDBP-24726.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRFIP2
Protein Name leucine rich repeat (in FLII) interacting protein 2
Synonyms HUFI-2;
Species Homo sapiens
Ensembl Protein ENSP00000338727
InnateDB Gene IDBG-24724 (LRRFIP2)
Protein Structure
UniProt Annotation
Function May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269PubMed:15677333, ECO:0000269PubMed:19265123}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed, with highest levels in heart and skeletal muscle. {ECO:0000269PubMed:10366446}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030275 LRR domain binding
GO:0046983 protein dimerization activity
Biological Process
GO:0008150 biological_process
GO:0016055 Wnt signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro IPR009053 Prefoldin
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR019139 Leucine-rich repeat flightless-interacting protein
PFAM PF00010
PF09738
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y608
PhosphoSite PhosphoSite-Q9Y608
TrEMBL C9JJC9
UniProt Splice Variant
Entrez Gene 9209
UniGene Hs.740522
RefSeq NP_006300
HUGO HGNC:6703
OMIM 614043
CCDS CCDS2664
HPRD 10061
IMGT
EMBL AC006583 AC126118 AF115509 AK000255 AK291514 BC053668 CR749705
GenPept AAD41257 AAH53668 BAA91035 BAF84203 CAH18481

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca