InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRDM14

Summary

InnateDB Protein

IDBP-24785.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDM14

Protein Name

PR domain containing 14

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000276594

InnateDB Gene

IDBG-24783 (PRDM14)

Protein Structure

UniProt Annotation

Function

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. {ECO:0000250, ECO:0000269PubMed:17942894, ECO:0000269PubMed:20953172}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17942894}.

Disease Associations

Tissue Specificity

Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level). {ECO:0000269PubMed:17942894, ECO:0000269PubMed:20953172}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001708	cell fate specification
GO:0001827	inner cell mass cell fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007281	germ cell development
GO:0009566	fertilization
GO:0010468	regulation of gene expression
GO:0030718	germ-line stem cell maintenance
GO:0032259	methylation
GO:0034972	histone H3-R26 methylation
GO:0040029	regulation of gene expression, epigenetic
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0044030	regulation of DNA methylation
GO:0048873	homeostasis of number of cells within a tissue