InnateDB Protein
|
IDBP-248083.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
KRTAP4-7
|
Protein Name
|
keratin associated protein 4-7
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000375236
|
InnateDB Gene
|
IDBG-408327 (KRTAP4-7)
|
Protein Structure
|
|
Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
Expressed in the hair follicles. {ECO:0000269PubMed:15955084}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR002494
Keratin-associated protein
|
PFAM |
PF01500
PF13885
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9BYR0
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
101930568
|
UniGene |
|
RefSeq |
NP_149050
|
HUGO |
HGNC:18898
|
OMIM |
|
CCDS |
CCDS45673
|
HPRD |
|
IMGT |
|
EMBL |
AC100808
AJ406939
BC126421
BC126423
|
GenPept |
AAI26422
AAI26424
CAC27578
|
|
|