InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube1y1

Summary

InnateDB Protein

IDBP-248626.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube1y1

Protein Name

ubiquitin-activating enzyme E1, Chr Y 1

Synonyms

A1s9Y-1; Sby; Ube-2; Ube1ay; Ube1y; Ube1y-1; Ube1y1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111560

InnateDB Gene

IDBG-127660 (Ube1y1)

Protein Structure

UniProt Annotation

Function

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in testis in A spermatogonia and spermatids but not (or at very low levels) in pachytene spermatocytes. Also expressed in Y-bearing ovaries and at very low levels in adrenal gland. {ECO:0000269PubMed:8948595}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0016874	ligase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0016567	protein ubiquitination

Cellular Component

Protein Structure and Domains

PDB ID

MGI:98891

InterPro

IPR000011 Ubiquitin/SUMO-activating enzyme E1
IPR000127 Ubiquitin-activating enzyme repeat
IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR009036 Molybdenum cofactor biosynthesis, MoeB
IPR018075 Ubiquitin-activating enzyme, E1
IPR018965 Ubiquitin-activating enzyme e1, C-terminal
IPR019572 Ubiquitin-activating enzyme

PFAM

PF02134
PF00899
PF09358
PF10585

PRINTS

PR01849

PIRSF

SMART

SM00985

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt