InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPEF2

Summary

InnateDB Protein

IDBP-24869.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPEF2

Protein Name

protein phosphatase, EF-hand calcium binding domain 2

Synonyms

PPP7CB;

Species

Homo sapiens

Ensembl Protein

ENSP00000286719

InnateDB Gene

IDBG-24867 (PPEF2)

Protein Structure

UniProt Annotation

Function

May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.

Subcellular Localization

Cytoplasm {ECO:0000305}. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Note=Localized to photoreceptors, PPEF-2(L) is at least 2 fold more abundant in rod inner segments than in the outer segments.

Disease Associations

Tissue Specificity

Retinal specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005506	iron ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding
GO:0030544	Hsp70 protein binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007601	visual perception
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0043405	regulation of MAP kinase activity
GO:0043409	negative regulation of MAPK cascade
GO:0043506	regulation of JUN kinase activity
GO:0050906	detection of stimulus involved in sensory perception

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR012008 Serine/threonine protein phosphatase, EF-hand-containing
IPR013235 PPP domain
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00036
PF13202
PF13405
PF00149
PF08321

PRINTS

PR00114

PIRSF

PIRSF000912

SMART

SM00054
SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References