InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grin2a

Summary

InnateDB Protein

IDBP-248771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grin2a

Protein Name

glutamate receptor, ionotropic, NMDA2A (epsilon 1)

Synonyms

GluN2A; NMDAR2A; NR2A;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111501

InnateDB Gene

IDBG-131990 (Grin2a)

Protein Structure

UniProt Annotation

Function

NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14602821}; Multi-pass membrane protein {ECO:0000269PubMed:14602821}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269PubMed:14602821}; Multi-pass membrane protein {ECO:0000269PubMed:14602821}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0001964	startle response
GO:0001975	response to amphetamine
GO:0006810	transport
GO:0006816	calcium ion transport
GO:0007268	synaptic transmission
GO:0007611	learning or memory
GO:0007612	learning
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0008104	protein localization
GO:0008542	visual learning
GO:0009611	response to wounding
GO:0019233	sensory perception of pain
GO:0022008	neurogenesis
GO:0030431	sleep
GO:0033058	directional locomotion
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0040011	locomotion
GO:0042177	negative regulation of protein catabolic process
GO:0042391	regulation of membrane potential
GO:0042417	dopamine metabolic process
GO:0042428	serotonin metabolic process
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0045471	response to ethanol
GO:0048167	regulation of synaptic plasticity
GO:0050804	regulation of synaptic transmission
GO:0051930	regulation of sensory perception of pain
GO:0060078	regulation of postsynaptic membrane potential
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0008021	synaptic vesicle
GO:0009986	cell surface
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

MGI:95820

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10565
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt