InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nde1

Summary

InnateDB Protein

IDBP-248849.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nde1

Protein Name

nuclear distribution gene E homolog 1 (A nidulans)

Synonyms

2810027M15Rik; AU042936; AW822251; mNudE; Nude;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111461

InnateDB Gene

IDBG-134578 (Nde1)

Protein Structure

UniProt Annotation

Function

Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. {ECO:0000269PubMed:15473967}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF- dependent manner. Also localizes to the cleavage furrow during cytokinesis.

Disease Associations

Tissue Specificity

Highly expressed in ovary. Also expressed in brain, heart, kidney, large intestine, liver, lung, small intestine and testis. {ECO:0000269PubMed:11163258, ECO:0000269PubMed:11163259}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0001764	neuron migration
GO:0007020	microtubule nucleation
GO:0007067	mitotic nuclear division
GO:0007405	neuroblast proliferation
GO:0021987	cerebral cortex development
GO:0030900	forebrain development
GO:0031023	microtubule organizing center organization
GO:0047496	vesicle transport along microtubule
GO:0051298	centrosome duplication
GO:0051303	establishment of chromosome localization

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005874	microtubule
GO:0031616	spindle pole centrosome
GO:0032154	cleavage furrow