InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2v2

Summary

InnateDB Protein

IDBP-248886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2v2

Protein Name

ubiquitin-conjugating enzyme E2 variant 2

Synonyms

1110021H13Rik; 4632410D19Rik; 5730524P06Rik; 6820402M05; AI848315; C81524; MMS2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111443

InnateDB Gene

IDBG-135622 (Ube2v2)

Protein Structure

UniProt Annotation

Function

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. {ECO:0000269PubMed:11406273}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0010976	positive regulation of neuron projection development
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042275	error-free postreplication DNA repair
GO:0043524	negative regulation of neuron apoptotic process
GO:0045739	positive regulation of DNA repair
GO:0051965	positive regulation of synapse assembly