Version 5.4
Mus musculus Protein: Ube2v2
Summary
InnateDB Protein IDBP-248888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube2v2
Protein Name ubiquitin-conjugating enzyme E2 variant 2
Synonyms 1110021H13Rik; 4632410D19Rik; 5730524P06Rik; 6820402M05; AI848315; C81524; MMS2;
Species Mus musculus
Ensembl Protein ENSMUSP00000111442
InnateDB Gene IDBG-135622 (Ube2v2)
Protein Structure
UniProt Annotation
Function Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. {ECO:0000269PubMed:11406273}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0042275 error-free postreplication DNA repair
Cellular Component
Protein Structure and Domains
PDB ID MGI:1917870
InterPro IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D2M8
PhosphoSite PhosphoSite-Q9D2M8
TrEMBL B2KF55
UniProt Splice Variant
Entrez Gene 70620
UniGene Mm.482264
RefSeq NP_001152823
MGI ID
MGI Symbol Ube2v2
OMIM
CCDS CCDS49771
HPRD
IMGT
EMBL AF303828 AK017786 AK019486 AK028472 AK028742 AK031233 AK033016 BC029742 BC058374 BC083098 CT010522
GenPept AAG22084 AAH29742 AAH58374 AAH83098 BAB30932 BAB31753 BAC25968 BAC26094 BAC27311 BAC28128 CAO77942

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca