Version 5.4
Mus musculus Protein: Foxp3
Summary
InnateDB Protein IDBP-248980.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Foxp3
Protein Name forkhead box P3
Synonyms JM2; scurfin; sf;
Species Mus musculus
Ensembl Protein ENSMUSP00000111404
InnateDB Gene IDBG-128986 (Foxp3)
Protein Structure
UniProt Annotation
Function Probable transcription factor. Plays a critical role in the control of immune response.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00089}.
Disease Associations Note=Defects in Foxp3 are the cause of the scurfy phenotype (sf). It results in a lethal disorder of immunoregulation, characterized by infections, diarrhea, anemia, thrombocytopenia, hypogonadism, gastrointestinal bleeding, lymphadenopathy and leukocytosis.
Tissue Specificity High level of expression in thymus and spleen.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 385 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 385 [view]
Protein-Protein 377 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0008301 DNA binding, bending
GO:0035035 histone acetyltransferase binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0051525 NFAT protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001782 B cell homeostasis
GO:0001816 cytokine production
GO:0002262 myeloid cell homeostasis
GO:0002329 pre-B cell differentiation
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0002456 T cell mediated immunity
GO:0002507 tolerance induction
GO:0002513 tolerance induction to self antigen
GO:0002637 regulation of immunoglobulin production
GO:0002639 positive regulation of immunoglobulin production
GO:0002666 positive regulation of T cell tolerance induction
GO:0002669 positive regulation of T cell anergy
GO:0002677 negative regulation of chronic inflammatory response
GO:0002725 negative regulation of T cell cytokine production
GO:0002851 positive regulation of peripheral T cell tolerance induction
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007389 pattern specification process
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0010628 positive regulation of gene expression
GO:0030324 lung development
GO:0031064 negative regulation of histone deacetylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032689 negative regulation of interferon-gamma production
GO:0032693 negative regulation of interleukin-10 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032753 positive regulation of interleukin-4 production
GO:0032792 negative regulation of CREB transcription factor activity
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0033152 immunoglobulin V(D)J recombination
GO:0035066 positive regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0042036 negative regulation of cytokine biosynthetic process
GO:0042110 T cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045066 regulatory T cell differentiation
GO:0045077 negative regulation of interferon-gamma biosynthetic process
GO:0045085 negative regulation of interleukin-2 biosynthetic process
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048294 negative regulation of isotype switching to IgE isotypes
GO:0048302 regulation of isotype switching to IgG isotypes
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050710 negative regulation of cytokine secretion
GO:0050728 negative regulation of inflammatory response
GO:0050777 negative regulation of immune response
GO:0050852 T cell receptor signaling pathway
GO:0055007 cardiac muscle cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1891436
InterPro IPR001766 Transcription factor, fork head
PFAM PF00250
PRINTS PR00053
PIRSF
SMART SM00339
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99JB6
PhosphoSite PhosphoSite-Q99JB6
TrEMBL Q53Z59
UniProt Splice Variant
Entrez Gene 20371
UniGene Mm.182291
RefSeq NP_473380
MGI ID 4I1L
MGI Symbol Foxp3
OMIM
CCDS CCDS29965
HPRD
IMGT
EMBL AF277991 AF277992 AF277994 AK157447 AY357712 AY357713 BC132333 BC132335 CH466638 DQ387959
GenPept AAG53605 AAG53606 AAG53608 AAI32334 AAI32336 AAR11305 AAR11306 ABD52722 BAE34089 EDL33899 EDL33900

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca