InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmem173

Summary

InnateDB Protein

IDBP-249021.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmem173

Protein Name

transmembrane protein 173

Synonyms

2610307O08Rik; ERIS; Mita; MPYS; STING;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111393

InnateDB Gene

IDBG-137341 (Tmem173)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0035438	cyclic-di-GMP binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0061507	cyclic-GMP-AMP binding

Biological Process

GO:0002218	activation of innate immune response
GO:0002230	positive regulation of defense response to virus by host
GO:0006915	apoptotic process
GO:0032092	positive regulation of protein binding
GO:0032481	positive regulation of type I interferon production
GO:0032608	interferon-beta production
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0035458	cellular response to interferon-beta
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0071360	cellular response to exogenous dsRNA

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm