Version 5.4
Homo sapiens Protein: TRAM1
Summary
InnateDB Protein IDBP-24903.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAM1
Protein Name translocation associated membrane protein 1
Synonyms PNAS8; TRAM; TRAMP;
Species Homo sapiens
Ensembl Protein ENSP00000262213
InnateDB Gene IDBG-24901 (TRAM1)
Protein Structure
UniProt Annotation
Function Stimulatory or required for the translocation of secretory proteins across the ER membrane.
Subcellular Localization Endoplasmic reticulum membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006634 TRAM/LAG1/CLN8 homology domain
IPR013599 TRAM1-like protein
IPR016447 Translocation associated membrane protein
PFAM PF03798
PF08390
PRINTS
PIRSF PIRSF005449
SMART SM00724
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15629
PhosphoSite PhosphoSite-Q15629
TrEMBL Q6FHL3
UniProt Splice Variant
Entrez Gene 23471
UniGene Hs.703860
RefSeq NP_055109
HUGO HGNC:20568
OMIM 605190
CCDS CCDS6207
HPRD 05545
IMGT
EMBL AC022731 AC120194 AK292777 AK303411 BC000687 BC037738 BT007359 CH471068 CR541739 X63679
GenPept AAH00687 AAH37738 AAP36023 BAF85466 BAG64464 CAA45218 CAG46539 EAW86966 EAW86967 EAW86968

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca