InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hic2

Summary

InnateDB Protein

IDBP-249066.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hic2

Protein Name

hypermethylated in cancer 2

Synonyms

AA409108; HRG22; mKIAA1020;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111362

InnateDB Gene

IDBG-138408 (Hic2)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005925	focal adhesion

Protein Structure and Domains

PDB ID

MGI:1929869

InterPro

IPR000210 BTB/POZ-like
IPR007087 Zinc finger, C2H2
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR015880 Zinc finger, C2H2-like

PFAM

PF00096
PF00651

PRINTS

PIRSF

SMART

SM00225
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JLZ6

PhosphoSite

PhosphoSite-Q9JLZ6

TrEMBL

UniProt Splice Variant

Entrez Gene

58180

UniGene

Mm.470636

RefSeq

MGI ID

MGI Symbol

Hic2

OMIM

CCDS

HPRD

IMGT

EMBL

AF117382 AJ868292 AK084975 AK129266 AK145386 AK156332 AK157276 BC065124

GenPept

AAF28801 AAH65124 BAC39326 BAC98076 BAE26404 BAE33679 BAE34025 CAI30631