InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aifm3

Summary

InnateDB Protein

IDBP-249092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aifm3

Protein Name

apoptosis-inducing factor, mitochondrion-associated 3

Synonyms

2810401C16Rik; AI840249; Aifl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111349

InnateDB Gene

IDBG-138951 (Aifm3)

Protein Structure

UniProt Annotation

Function

Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0050660	flavin adenine dinucleotide binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005783	endoplasmic reticulum

Protein Structure and Domains

PDB ID

MGI:1919418

InterPro

IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR016156 FAD/NAD-linked reductase, dimerisation domain
IPR017941 Rieske [2Fe-2S] iron-sulphur domain
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00070
PF00355
PF07992

PRINTS

PR00469
PR00368

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3TY86