InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pqbp1

Summary

InnateDB Protein

IDBP-249153.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pqbp1

Protein Name

polyglutamine binding protein 1

Synonyms

npw38; PQBP-1; Sfc2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111318

InnateDB Gene

IDBG-129707 (Pqbp1)

Protein Structure

UniProt Annotation

Function

Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (By similarity). Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658). {ECO:0000250, ECO:0000269PubMed:23512658}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:23512658}. Nucleus speckle {ECO:0000269PubMed:23512658}. Note=Colocalized with ATXN1 in nuclear inclusion bodies. Colocalized with POU3F2 (By similarity). Colocalizes with SRSF2 in nuclear speckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in brain cortex and hippocampus neurons (at protein level). Expressed in brain with high level in cerebellar cortex, hippocampus and olfactory bulb. {ECO:0000269PubMed:10332029, ECO:0000269PubMed:23512658}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0034063	stress granule assembly
GO:0048814	regulation of dendrite morphogenesis