InnateDB Protein
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IDBP-249253.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Comt
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Protein Name
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catechol-O-methyltransferase
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Synonyms
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Comt1; D16Wsu103e; D330014B15Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000111272
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InnateDB Gene
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IDBG-141739 (Comt)
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Protein Structure
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Function |
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
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Subcellular Localization |
Isoform Soluble: Cytoplasm.Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:88470
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InterPro |
IPR002935
O-methyltransferase, family 3
IPR017128
Catechol O-methyltransferase, eukaryotic
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
PF01596
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PRINTS |
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PIRSF |
PIRSF037177
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O88587
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PhosphoSite |
PhosphoSite-O88587
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TrEMBL |
D3Z227
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UniProt Splice Variant |
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Entrez Gene |
12846
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UniGene |
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RefSeq |
NP_031770
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MGI ID |
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MGI Symbol |
Comt
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OMIM |
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CCDS |
CCDS28021
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HPRD |
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IMGT |
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EMBL |
AC133487
AF076156
AK148311
BC010402
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GenPept |
AAC33334
AAH10402
BAE28473
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