InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fpr3

Summary

InnateDB Protein

IDBP-249350.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fpr3

Protein Name

formyl peptide receptor 3

Synonyms

ALX; Fpr-rs1; Fpr-s1; Fprl1; LXA4-R; Lxa4r;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111227

InnateDB Gene

IDBG-249348 (Fpr3)

Protein Structure

UniProt Annotation

Function

Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states. {ECO:0000269PubMed:19387439}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (PubMed:19387439). {ECO:0000269PubMed:19387439, ECO:0000269PubMed:19497865, ECO:0000269PubMed:9151906, ECO:0000269PubMed:9722950}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0007186	G-protein coupled receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1194495

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002234 Anaphylatoxin chemotactic receptor family
IPR002258 DEZ orphan receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01104
PR01126

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O08790