Version 5.4
Mus musculus Protein: Mid1ip1
Summary
InnateDB Protein IDBP-249449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mid1ip1
Protein Name Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
Synonyms 3110038L01Rik; Mig12; S14R;
Species Mus musculus
Ensembl Protein ENSMUSP00000111186
InnateDB Gene IDBG-131797 (Mid1ip1)
Protein Structure
UniProt Annotation
Function Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules. {ECO:0000269PubMed:15070402, ECO:0000269PubMed:20457939, ECO:0000269PubMed:20952656}.
Subcellular Localization Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Disease Associations
Tissue Specificity During embryonic development, expressed mainly in the neuroepithelial midline, urogenital apparatus and digits. Detected in adult white fat, liver, heart, brain and kidney. Expressed at very low levels in lactating mammary gland. {ECO:0000269PubMed:15070402, ECO:0000269PubMed:15890771, ECO:0000269PubMed:20457939}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0006629 lipid metabolic process
GO:0007026 negative regulation of microtubule depolymerization
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0046890 regulation of lipid biosynthetic process
GO:0051258 protein polymerization
GO:0051351 positive regulation of ligase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID MGI:1915291
InterPro IPR009786 Spot 14 family
PFAM PF07084
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQ20
PhosphoSite PhosphoSite-Q9CQ20
TrEMBL Q4FK31
UniProt Splice Variant
Entrez Gene 68041
UniGene Mm.412269
RefSeq NP_001160107
MGI ID
MGI Symbol Mid1ip1
OMIM
CCDS CCDS30018
HPRD
IMGT
EMBL AK004021 AK014143 AK090003 AK131619 AK151153 AK159166 AK160062 AK172143 AL671335 AY263385 BC004014 BC010778 BC052899 CH466584 CT010221
GenPept AAH04014 AAH10778 AAH52899 AAP87014 BAB23129 BAB29178 BAC41039 BAE20724 BAE30159 BAE34868 BAE35598 BAE42845 CAJ18429 EDL35682

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca