InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cask

Summary

InnateDB Protein

IDBP-249625.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cask

Protein Name

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Synonyms

DXPri1; DXRib1; LIN-2; mLin-2; Pals3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111096

InnateDB Gene

IDBG-133241 (Cask)

Protein Structure

UniProt Annotation

Function

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. {ECO:0000269PubMed:10749215}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042043	neurexin family protein binding

Biological Process

GO:0001953	negative regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0010839	negative regulation of keratinocyte proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0061045	negative regulation of wound healing
GO:0070509	calcium ion import
GO:0090280	positive regulation of calcium ion import
GO:0090288	negative regulation of cellular response to growth factor stimulus

Cellular Component

GO:0005604	basement membrane
GO:0005634	nucleus
GO:0005652	nuclear lamina
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016363	nuclear matrix
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:1309489

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR001478 PDZ domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR004172 L27
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR014775 L27, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM