InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Met

Summary

InnateDB Protein

IDBP-249635.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Met

Protein Name

met proto-oncogene

Synonyms

AI838057; c-Met; HGF; HGFR; Par4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111103

InnateDB Gene

IDBG-129003 (Met)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005008	hepatocyte growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001889	liver development
GO:0001890	placenta development
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0007517	muscle organ development
GO:0007519	skeletal muscle tissue development
GO:0010828	positive regulation of glucose transport
GO:0014812	muscle cell migration
GO:0014902	myotube differentiation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030534	adult behavior
GO:0042593	glucose homeostasis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050918	positive chemotaxis
GO:0051450	myoblast proliferation
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0071526	semaphorin-plexin signaling pathway
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2001028	positive regulation of endothelial cell chemotaxis

Cellular Component

GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96969

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001627 Sema domain
IPR002165 Plexin
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR002909 IPT domain
IPR011009 Protein kinase-like domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold
IPR016244 Tyrosine-protein kinase, HGF/MSP receptor
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF01403
PF01437
PF01833

PRINTS

PR00109

PIRSF

PIRSF000617

SMART

SM00630
SM00220
SM00429
SM00423
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References