InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Steap4

Summary

InnateDB Protein

IDBP-249686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Steap4

Protein Name

STEAP family member 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111081

InnateDB Gene

IDBG-133094 (Steap4)

Protein Structure

UniProt Annotation

Function

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Inhibits anchorage-independent cell proliferation (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. {ECO:0000250, ECO:0000269PubMed:16609065, ECO:0000269PubMed:17482547, ECO:0000269PubMed:19660107}.

Subcellular Localization

Cell membrane. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in white and brown adipose tissues cells, as well as in muscle and liver cells. Detected in joints and spleens of arthritic mice. {ECO:0000269PubMed:14988015, ECO:0000269PubMed:19660107}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008823	cupric reductase activity
GO:0046872	metal ion binding
GO:0052851	ferric-chelate reductase (NADPH) activity

Biological Process

GO:0015677	copper ion import
GO:0045444	fat cell differentiation
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process
GO:0097461	ferric iron import into cell