Version 5.4
Mus musculus Protein: Pdpk1
Summary
InnateDB Protein IDBP-249690.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Pdpk1
Protein Name 3-phosphoinositide dependent protein kinase 1
Synonyms Pdk1;
Species Mus musculus
Ensembl Protein ENSMUSP00000111068
InnateDB Gene IDBG-145251 (Pdpk1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 59 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004676 3-phosphoinositide-dependent protein kinase activity
GO:0005158 insulin receptor binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006972 hyperosmotic response
GO:0007165 signal transduction
GO:0018107 peptidyl-threonine phosphorylation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032148 activation of protein kinase B activity
GO:0032869 cellular response to insulin stimulus
GO:0035556 intracellular signal transduction
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048041 focal adhesion assembly
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID MGI:1338068
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F2Z3Z9
UniProt Splice Variant
Entrez Gene 18607
UniGene Mm.408705
RefSeq
MGI ID
MGI Symbol Pdpk1
OMIM
CCDS
HPRD
IMGT
EMBL CT010502
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca