InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc12a2

Summary

InnateDB Protein

IDBP-249807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc12a2

Protein Name

solute carrier family 12, member 2

Synonyms

9330166H04Rik; mBSC2; Nkcc1; sy-ns;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111023

InnateDB Gene

IDBG-148401 (Slc12a2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008511	sodium:potassium:chloride symporter activity
GO:0008519	ammonium transmembrane transporter activity
GO:0015377	cation:chloride symporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0006821	chloride transport
GO:0006972	hyperosmotic response
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0015696	ammonium transport
GO:0030321	transepithelial chloride transport
GO:0035264	multicellular organism growth
GO:0045795	positive regulation of cell volume
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0055085	transmembrane transport
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060763	mammary duct terminal end bud growth
GO:0070634	transepithelial ammonium transport
GO:0072488	ammonium transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:101924

InterPro

IPR002443 Na/K/Cl co-transporter
IPR002444 Na/K/Cl co-transporter 1
IPR004841 Amino acid permease/ SLC12A domain
IPR004842 Na/K/Cl co-transporter superfamily
IPR013612 Amino acid permease, N-terminal

PFAM

PF00324
PF08403

PRINTS

PR01207
PR01208

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite