InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klhl13

Summary

InnateDB Protein

IDBP-249903.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klhl13

Protein Name

kelch-like 13 (Drosophila)

Synonyms

1200009K10Rik; AI451128; Bklhd2; D130072F20Rik; mKIAA1309;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110968

InnateDB Gene

IDBG-136215 (Klhl13)

Protein Structure

UniProt Annotation

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0000910	cytokinesis
GO:0007067	mitotic nuclear division
GO:0016567	protein ubiquitination

Cellular Component

GO:0031463

Cul3-RING ubiquitin ligase complex

Protein Structure and Domains

PDB ID

MGI:1914705

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt