Version 5.4
Homo sapiens Protein: FAM110C
Summary
InnateDB Protein IDBP-24991.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM110C
Protein Name family with sequence similarity 110, member C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000328347
InnateDB Gene IDBG-24989 (FAM110C)
Protein Structure
UniProt Annotation
Function May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. {ECO:0000269PubMed:17499476, ECO:0000269PubMed:19698782}.
Subcellular Localization Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with microtubules during interphase. Detected at the mitotic spindle poles. Colocalizes with AKT1 at the cell cortex.
Disease Associations
Tissue Specificity Detected in stomach, thyroid, trachea, adrenal gland and testis, and at low levels in prostate, ovary, intestine, colon, spinal cord and lymph node. {ECO:0000269PubMed:17499476}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043014 alpha-tubulin binding
Biological Process
GO:0030335 positive regulation of cell migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0060491 regulation of cell projection assembly
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005874 microtubule
GO:0005938 cell cortex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1W6H9
PhosphoSite PhosphoSite-Q1W6H9
TrEMBL
UniProt Splice Variant
Entrez Gene 642273
UniGene Hs.8379
RefSeq NP_001071178
HUGO HGNC:33340
OMIM 611395
CCDS CCDS42645
HPRD
IMGT
EMBL AC097643 DQ431183
GenPept ABD92775

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca