InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trp63

Summary

InnateDB Protein

IDBP-249921.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trp63

Protein Name

transformation related protein 63

Synonyms

AI462811; Ket; P51/P63; P63; P73l; Tp63; Trp53rp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110963

InnateDB Gene

IDBG-150133 (Trp63)

Protein Structure

UniProt Annotation

Function

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. {ECO:0000250, ECO:0000269PubMed:10227293, ECO:0000269PubMed:10227294, ECO:0000269PubMed:11932750, ECO:0000269PubMed:14729569, ECO:0000269PubMed:22197488}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14729569}.

Disease Associations

Tissue Specificity

Widely expressed, notably in thymus, prostate, placenta and skeletal muscle, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast and prostate express high levels of DeltaN-type isoforms. {ECO:0000269PubMed:9774969}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 116 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	116 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001736	establishment of planar polarity
GO:0001738	morphogenesis of a polarized epithelium
GO:0001942	hair follicle development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002064	epithelial cell development
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0007389	pattern specification process
GO:0007499	ectoderm and mesoderm interaction
GO:0007569	cell aging
GO:0008544	epidermis development
GO:0009887	organ morphogenesis
GO:0009954	proximal/distal pattern formation
GO:0010165	response to X-ray
GO:0010259	multicellular organismal aging
GO:0010332	response to gamma radiation
GO:0010481	epidermal cell division
GO:0010482	regulation of epidermal cell division
GO:0010838	positive regulation of keratinocyte proliferation
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0030326	embryonic limb morphogenesis
GO:0030850	prostate gland development
GO:0030855	epithelial cell differentiation
GO:0030859	polarized epithelial cell differentiation
GO:0031069	hair follicle morphogenesis
GO:0031571	mitotic G1 DNA damage checkpoint
GO:0034644	cellular response to UV
GO:0036342	post-anal tail morphogenesis
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066	negative regulation of apoptotic process
GO:0043523	regulation of neuron apoptotic process
GO:0043589	skin morphogenesis
GO:0043616	keratinocyte proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045617	negative regulation of keratinocyte differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048485	sympathetic nervous system development
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048745	smooth muscle tissue development
GO:0048807	female genitalia morphogenesis
GO:0051262	protein tetramerization
GO:0051289	protein homotetramerization
GO:0051402	neuron apoptotic process
GO:0060157	urinary bladder development
GO:0060197	cloacal septation
GO:0060513	prostatic bud formation
GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0061436	establishment of skin barrier
GO:2000271	positive regulation of fibroblast apoptotic process
GO:2000381	negative regulation of mesoderm development
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0030425	dendrite

Protein Structure and Domains

PDB ID

MGI:1330810

InterPro

IPR002117 p53 tumour suppressor family
IPR008967 p53-like transcription factor, DNA-binding
IPR010991 p53, tetramerisation domain
IPR011615 p53, DNA-binding domain

PFAM

PF07710
PF00870

PRINTS

PR00386

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88898