Version 5.4
Mus musculus Protein: Trp63
Summary
InnateDB Protein IDBP-249923.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Trp63
Protein Name transformation related protein 63
Synonyms AI462811; Ket; P51/P63; P63; P73l; Tp63; Trp53rp1;
Species Mus musculus
Ensembl Protein ENSMUSP00000110962
InnateDB Gene IDBG-150133 (Trp63)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 116 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 116 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001942 hair follicle development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002064 epithelial cell development
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007275 multicellular organismal development
GO:0007389 pattern specification process
GO:0007499 ectoderm and mesoderm interaction
GO:0007569 cell aging
GO:0008544 epidermis development
GO:0009887 organ morphogenesis
GO:0009954 proximal/distal pattern formation
GO:0010165 response to X-ray
GO:0010259 multicellular organismal aging
GO:0010332 response to gamma radiation
GO:0010481 epidermal cell division
GO:0010838 positive regulation of keratinocyte proliferation
GO:0030154 cell differentiation
GO:0030216 keratinocyte differentiation
GO:0030326 embryonic limb morphogenesis
GO:0030850 prostate gland development
GO:0030855 epithelial cell differentiation
GO:0030859 polarized epithelial cell differentiation
GO:0031069 hair follicle morphogenesis
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0034644 cellular response to UV
GO:0036342 post-anal tail morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 negative regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043589 skin morphogenesis
GO:0043616 keratinocyte proliferation
GO:0045087 innate immune response (InnateDB)
GO:0045617 negative regulation of keratinocyte differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048485 sympathetic nervous system development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048745 smooth muscle tissue development
GO:0048807 female genitalia morphogenesis
GO:0051402 neuron apoptotic process
GO:0060157 urinary bladder development
GO:0060197 cloacal septation
GO:0060513 prostatic bud formation
GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:2000381 negative regulation of mesoderm development
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005829 cytosol
GO:0030425 dendrite
Protein Structure and Domains
PDB ID MGI:1330810
InterPro IPR008967 p53-like transcription factor, DNA-binding
IPR011615 p53, DNA-binding domain
PFAM PF00870
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z7K2
UniProt Splice Variant
Entrez Gene 22061
UniGene Mm.398545
RefSeq
MGI ID
MGI Symbol Trp63
OMIM
CCDS
HPRD
IMGT
EMBL AC109213 AC113020
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca