InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trp63

Summary

InnateDB Protein

IDBP-249925.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Trp63

Protein Name

transformation related protein 63

Synonyms

AI462811; Ket; P51/P63; P63; P73l; Tp63; Trp53rp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110961

InnateDB Gene

IDBG-150133 (Trp63)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 116 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	116 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001736	establishment of planar polarity
GO:0001738	morphogenesis of a polarized epithelium
GO:0001942	hair follicle development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002064	epithelial cell development
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007275	multicellular organismal development
GO:0007389	pattern specification process
GO:0007499	ectoderm and mesoderm interaction
GO:0007569	cell aging
GO:0008544	epidermis development
GO:0009887	organ morphogenesis
GO:0009954	proximal/distal pattern formation
GO:0010165	response to X-ray
GO:0010259	multicellular organismal aging
GO:0010332	response to gamma radiation
GO:0010481	epidermal cell division
GO:0010838	positive regulation of keratinocyte proliferation
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0030326	embryonic limb morphogenesis
GO:0030850	prostate gland development
GO:0030855	epithelial cell differentiation
GO:0030859	polarized epithelial cell differentiation
GO:0031069	hair follicle morphogenesis
GO:0031571	mitotic G1 DNA damage checkpoint
GO:0034644	cellular response to UV
GO:0036342	post-anal tail morphogenesis
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066	negative regulation of apoptotic process
GO:0043523	regulation of neuron apoptotic process
GO:0043589	skin morphogenesis
GO:0043616	keratinocyte proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045617	negative regulation of keratinocyte differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048485	sympathetic nervous system development
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048745	smooth muscle tissue development
GO:0048807	female genitalia morphogenesis
GO:0051262	protein tetramerization
GO:0051402	neuron apoptotic process
GO:0060157	urinary bladder development
GO:0060197	cloacal septation
GO:0060513	prostatic bud formation
GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:2000381	negative regulation of mesoderm development
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005829	cytosol
GO:0030425	dendrite

Protein Structure and Domains

PDB ID

MGI:1330810

InterPro

IPR001660 Sterile alpha motif domain
IPR002117 p53 tumour suppressor family
IPR008967 p53-like transcription factor, DNA-binding
IPR010991 p53, tetramerisation domain
IPR011510 Sterile alpha motif, type 2
IPR011615 p53, DNA-binding domain
IPR013761 Sterile alpha motif/pointed domain

PFAM

PF07710
PF07647
PF00870

PRINTS

PR00386

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt