Version 5.4
Mus musculus Protein: Pdgfrb
Summary
InnateDB Protein IDBP-249961.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdgfrb
Protein Name platelet derived growth factor receptor, beta polypeptide
Synonyms AI528809; CD140b; Pdgfr; PDGFR-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000110929
InnateDB Gene IDBG-150834 (Pdgfrb)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 72 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005019 platelet-derived growth factor beta-receptor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0038085 vascular endothelial growth factor binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001894 tissue homeostasis
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006468 protein phosphorylation
GO:0006807 nitrogen compound metabolic process
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0009636 response to toxic substance
GO:0010863 positive regulation of phospholipase C activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030325 adrenal gland development
GO:0030335 positive regulation of cell migration
GO:0032355 response to estradiol
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032526 response to retinoic acid
GO:0032967 positive regulation of collagen biosynthetic process
GO:0034405 response to fluid shear stress
GO:0035789 metanephric mesenchymal cell migration
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042542 response to hydrogen peroxide
GO:0043066 negative regulation of apoptotic process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0046488 phosphatidylinositol metabolic process
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048705 skeletal system morphogenesis
GO:0048745 smooth muscle tissue development
GO:0048839 inner ear development
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0055093 response to hyperoxia
GO:0060326 cell chemotaxis
GO:0072075 metanephric mesenchyme development
GO:0072275 metanephric glomerulus morphogenesis
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031226 intrinsic component of plasma membrane
Protein Structure and Domains
PDB ID MGI:97531
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF07679
PF00047
PRINTS PR00109
PIRSF PIRSF000615
PIRSF500947
SMART SM00220
SM00408
SM00409
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9QPE2
UniProt Splice Variant
Entrez Gene 18596
UniGene Mm.471814
RefSeq
MGI ID
MGI Symbol Pdgfrb
OMIM
CCDS
HPRD
IMGT
EMBL AC124448
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca