Version 5.4
Homo sapiens Protein: PCDH11Y
Summary
InnateDB Protein IDBP-25.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDH11Y
Protein Name protocadherin 11 Y-linked
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355419
InnateDB Gene IDBG-21 (PCDH11Y)
Protein Structure
UniProt Annotation
Function Potential calcium-dependent cell-adhesion protein.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations Note=A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.
Tissue Specificity Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells. {ECO:0000269PubMed:11003707, ECO:0000269PubMed:12420223, ECO:0000269PubMed:14727141, ECO:0000269PubMed:16331680}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002126 Cadherin
IPR013164 Cadherin, N-terminal
IPR013585 Protocadherin
IPR015919 Cadherin-like
PFAM PF00028
PF08266
PF08374
PRINTS PR00205
PIRSF
SMART SM00112
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZA8
PhosphoSite PhosphoSite-Q9BZA8
TrEMBL
UniProt Splice Variant
Entrez Gene 83259
UniGene Hs.661308
RefSeq NP_116754
HUGO HGNC:15813
OMIM 400022
CCDS CCDS14777
HPRD 11847
IMGT
EMBL AF277053 AF332216 AF332217 AJ276803 AJ564958 AJ564959 AJ564960 AJ564961 AJ564962 AJ564963 AJ564966 AJ564969
GenPept AAK13468 AAK13469 AAL55729 CAC13122 CAD92429 CAD92430 CAD92431 CAD92432 CAD92433 CAD92434 CAD92437 CAD92440

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca