InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Napepld

Summary

InnateDB Protein

IDBP-250108.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Napepld

Protein Name

N-acyl phosphatidylethanolamine phospholipase D

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110872

InnateDB Gene

IDBG-138207 (Napepld)

Protein Structure

UniProt Annotation

Function

Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors. {ECO:0000269PubMed:14634025}.

Subcellular Localization

Membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highest expression in brain, kidney and testis (at protein level). {ECO:0000269PubMed:14634025}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity

Biological Process

GO:0009395

phospholipid catabolic process

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

MGI:2140885

InterPro

IPR001279 Beta-lactamase-like

PFAM

PF00753

PRINTS

PIRSF

SMART

SM00849

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BH82

PhosphoSite

PhosphoSite-Q8BH82

TrEMBL

UniProt Splice Variant

Entrez Gene

242864

UniGene

Mm.153292

RefSeq

XP_006535772

MGI ID

MGI Symbol

Napepld

OMIM

CCDS

CCDS19105

HPRD

IMGT

EMBL

AB112350 AK049135 AK080888 AK141585 BC062890

GenPept

AAH62890 BAC33563 BAC38064 BAD02397 BAE24749