Version 5.4
Mus musculus Protein: Ptp4a1
Summary
InnateDB Protein IDBP-250156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptp4a1
Protein Name protein tyrosine phosphatase 4a1
Synonyms AA415290; AU019864; C130021B01; Prl-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000110861
InnateDB Gene IDBG-140089 (Ptp4a1)
Protein Structure
UniProt Annotation
Function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:10747914}. Early endosome {ECO:0000269PubMed:10747914}. Endoplasmic reticulum {ECO:0000269PubMed:10747914}. Cytoplasm {ECO:0000269PubMed:10747914}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:10747914}. Note=And mitotic spindle.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0004727 prenylated protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0007049 cell cycle
GO:0007275 multicellular organismal development
GO:0016311 dephosphorylation
GO:0030335 positive regulation of cell migration
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005768 endosome
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005819 spindle
GO:0005886 plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
Protein Structure and Domains
PDB ID MGI:1277096
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PF00782
PRINTS PR00700
PIRSF
SMART SM00194
SM00404
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q63739
PhosphoSite PhosphoSite-Q63739
TrEMBL B9EKL6
UniProt Splice Variant
Entrez Gene 19243
UniGene Mm.487268
RefSeq
MGI ID
MGI Symbol Ptp4a1
OMIM
CCDS CCDS14858
HPRD
IMGT
EMBL AF064943 AK081491 AK148288 AK150506 AK151533 BC055039 BC086787 BC094447 BC150972 BC150981 CH466536 CH466669 U84411
GenPept AAB58913 AAH55039 AAH86787 AAH94447 AAI50973 AAI50982 BAC38233 BAE28460 BAE29619 BAE30480 EDL14422 EDL20880

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca