InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kirrel3

Summary

InnateDB Protein

IDBP-250263.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kirrel3

Protein Name

kin of IRRE like 3 (Drosophila)

Synonyms

1500010O20Rik; 2900036G11Rik; mKIAA1867; NEPH2; SST4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110801

InnateDB Gene

IDBG-147743 (Kirrel3)

Protein Structure

UniProt Annotation

Function

Could be involved in the hematopoietic supportive capacity of stroma cells. The secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12665856}; Single-pass type I membrane protein {ECO:0000269PubMed:12665856}.Processed kin of IRRE-like protein 3: Secreted.

Disease Associations

Tissue Specificity

Expressed principally in adult brain, bone marrow and stromal cells. {ECO:0000269PubMed:12665856}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030165	PDZ domain binding

Biological Process

GO:0001764	neuron migration
GO:0002121	inter-male aggressive behavior
GO:0021740	principal sensory nucleus of trigeminal nerve development
GO:0030097	hemopoiesis
GO:0048812	neuron projection morphogenesis
GO:0072102	glomerulus morphogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043198	dendritic shaft

Protein Structure and Domains

PDB ID

MGI:1914953

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BR86