InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnk2

Summary

InnateDB Protein

IDBP-250318.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Tnk2

Protein Name

tyrosine kinase, non-receptor, 2

Synonyms

Ack; Ack-1; Ack1; Cdgip; Pyk1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110779

InnateDB Gene

IDBG-154521 (Tnk2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:2000369	regulation of clathrin-mediated endocytosis

Cellular Component

GO:0005634	nucleus
GO:0005905	coated pit
GO:0030136	clathrin-coated vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043025	neuronal cell body
GO:0070436	Grb2-EGFR complex

Protein Structure and Domains

PDB ID

MGI:1858308

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR009060 UBA-like
IPR011009 Protein kinase-like domain
IPR013761 Sterile alpha motif/pointed domain
IPR015116 Cdc42 binding domain like
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021619 EGFR receptor inhibitor Mig-6

PFAM

PF00069
PF07714
PF00018
PF14604
PF09027
PF11555

PRINTS

PR00109
PR00452

PIRSF

SMART

SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt