InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cul4b

Summary

InnateDB Protein

IDBP-250334.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cul4b

Protein Name

cullin 4B

Synonyms

2700050M05Rik; AA409770; CUL-4B; mKIAA0695;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110771

InnateDB Gene

IDBG-140168 (Cul4b)

Protein Structure

UniProt Annotation

Function

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation- induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (By similarity). {ECO:0000250UniProtKB:Q13620}.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:Q13620}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 292 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	292 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006281	DNA repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0016567	protein ubiquitination
GO:0045732	positive regulation of protein catabolic process
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle