InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnh2

Summary

InnateDB Protein

IDBP-250372.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnh2

Protein Name

potassium voltage-gated channel, subfamily H (eag-related), member 2

Synonyms

AI326795; ERG1; LQT; Lqt2; M-erg; Merg1; merg1a; merg1b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110750

InnateDB Gene

IDBG-140238 (Kcnh2)

Protein Structure

UniProt Annotation

Function

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in heart, brain and testis and at low levels in lung. Isoform 3 is expressed predominantly in heart. The expression of isoform 2 is low in all tissues tested.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000155	phosphorelay sensor kinase activity
GO:0005216	ion channel activity
GO:0005242	inward rectifier potassium channel activity
GO:0005249	voltage-gated potassium channel activity

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006811	ion transport
GO:0023014	signal transduction by phosphorylation
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0071805	potassium ion transmembrane transport
GO:0086091	regulation of heart rate by cardiac conduction

Cellular Component

GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1341722

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR003967 Potassium channel, voltage-dependent, ERG
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF00520
PF07885

PRINTS

PR01463
PR01470

PIRSF

SMART

SM00100

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt