Version 5.4
Mus musculus Protein: Nos3
Summary
InnateDB Protein IDBP-250382.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Nos3
Protein Name nitric oxide synthase 3, endothelial cell
Synonyms 2310065A03Rik; ecNOS; eNOS; Nos-3;
Species Mus musculus
Ensembl Protein ENSMUSP00000110742
InnateDB Gene IDBG-140461 (Nos3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003958 NADPH-hemoprotein reductase activity
GO:0004517 nitric-oxide synthase activity
GO:0005506 iron ion binding
GO:0005516 calmodulin binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0001525 angiogenesis
GO:0001542 ovulation from ovarian follicle
GO:0001701 in utero embryonic development
GO:0002028 regulation of sodium ion transport
GO:0003057 regulation of the force of heart contraction by chemical signal
GO:0006809 nitric oxide biosynthetic process
GO:0007263 nitric oxide mediated signal transduction
GO:0030324 lung development
GO:0031284 positive regulation of guanylate cyclase activity
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0043267 negative regulation of potassium ion transport
GO:0045776 negative regulation of blood pressure
GO:0045909 positive regulation of vasodilation
GO:0051346 negative regulation of hydrolase activity
GO:0051926 negative regulation of calcium ion transport
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:97362
InterPro IPR001094 Flavodoxin
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR003097 FAD-binding, type 1
IPR004030 Nitric oxide synthase, oxygenase domain
IPR008254 Flavodoxin/nitric oxide synthase
IPR012144 Nitric-oxide synthase, eukaryote
IPR017938 Riboflavin synthase-like beta-barrel
IPR029039 Flavoprotein-like
PFAM PF00175
PF00667
PF02898
PF00258
PRINTS PR00369
PR00371
PIRSF PIRSF000333
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9WTY7
UniProt Splice Variant
Entrez Gene 18127
UniGene Mm.258415
RefSeq
MGI ID
MGI Symbol Nos3
OMIM
CCDS
HPRD
IMGT
EMBL AC113055 AF091262
GenPept AAD22613

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca