Version 5.4
Mus musculus Protein: Sh2d1a
Summary
InnateDB Protein IDBP-250441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh2d1a
Protein Name SH2 domain protein 1A
Synonyms Gm686; SAP;
Species Mus musculus
Ensembl Protein ENSMUSP00000110722
InnateDB Gene IDBG-141610 (Sh2d1a)
Protein Structure
UniProt Annotation
Function Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. {ECO:0000269PubMed:16223723}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity T-cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0006959 humoral immune response
GO:0006968 cellular defense response
GO:0007267 cell-cell signaling
GO:0009967 positive regulation of signal transduction
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1328352
InterPro IPR000980 SH2 domain
PFAM PF00017
PF14633
PRINTS PR00401
PIRSF
SMART SM00252
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88890
PhosphoSite PhosphoSite-O88890
TrEMBL
UniProt Splice Variant
Entrez Gene 20400
UniGene
RefSeq
MGI ID
MGI Symbol Sh2d1a
OMIM
CCDS
HPRD
IMGT
EMBL AF072903 AF097632 AF097633 AF154503 AF154504 AF154505 AL831716
GenPept AAC62629 AAC95998 AAC95999 AAF14526 CAM19525

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca