InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tenm1

Summary

InnateDB Protein

IDBP-250447.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tenm1

Protein Name

odd Oz/ten-m homolog 1 (Drosophila)

Synonyms

Odz1; Odz2; TCAP-1; ten-1; Ten-m1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110711

InnateDB Gene

IDBG-141684 (Tenm1)

Protein Structure

UniProt Annotation

Function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). {ECO:0000250}.Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking. {ECO:0000269PubMed:15710242, ECO:0000269PubMed:17174479, ECO:0000269PubMed:17644218, ECO:0000269PubMed:17900539, ECO:0000269PubMed:18082275, ECO:0000269PubMed:19428634, ECO:0000269PubMed:20883474, ECO:0000269PubMed:21411044, ECO:0000269PubMed:22209827, ECO:0000269PubMed:22698694}.Ten-1 intracellular domain: Induces gene transcription activation. {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000269PubMed:23026563}; Single-pass membrane protein {ECO:0000269PubMed:23026563}. Note=Colocalizes with isoform 2 at the plasma membrane.Isoform 2: Cytoplasm. Cell membrane. Secreted {ECO:0000305}. Note=Transported to the cell membrane and probably secreted to function as an autocrine or paracrine signaling molecule. The lack of a hydrophobic segment sequence suggests that isoform 2 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.Ten-1 intracellular domain: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.Teneurin C-terminal-associated peptide: Nucleus {ECO:0000305}. Cytoplasm. Cell membrane. Note=Colocalizes with isoform 1 at the plasma membrane. Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are expressed in the brain. Isoform 2 is expressed in the granular layer of the dentate gyrus and the pyramidal layer (Py) of the CA1, CA2 and CA3 of the hippocampus (at protein level). Expressed in the cortex, thalamus, CA1, CA2, CA3, dentate gyrus and granular layer of the hippocampus. Weakly expressed in kidney, testis and lung. {ECO:0000269PubMed:10225957, ECO:0000269PubMed:12915301, ECO:0000269PubMed:15710242, ECO:0000269PubMed:23026563}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006359	regulation of transcription from RNA polymerase III promoter
GO:0006950	response to stress
GO:0007165	signal transduction
GO:0007218	neuropeptide signaling pathway
GO:0030838	positive regulation of actin filament polymerization
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0043406	positive regulation of MAP kinase activity
GO:0051491	positive regulation of filopodium assembly
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016363	nuclear matrix
GO:0016607	nuclear speck
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1345185

InterPro

IPR000742 Epidermal growth factor-like domain
IPR006530 YD repeat
IPR008969 Carboxypeptidase-like, regulatory domain
IPR009471 Teneurin intracellular, N-terminal
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF05593
PF06484
PF07974

PRINTS

PIRSF

SMART

SM00181

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WTS4