InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc4a2

Summary

InnateDB Protein

IDBP-250461.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc4a2

Protein Name

solute carrier family 4 (anion exchanger), member 2

Synonyms

Ae2; B3RP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110699

InnateDB Gene

IDBG-141190 (Slc4a2)

Protein Structure

UniProt Annotation

Function

Plasma membrane anion exchange protein of wide distribution.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform a is widely expressed at similar levels in all tissues examined. Isoforms B1 and B2 are predominantly expressed in stomach although they are also detected at lower levels in other tissues. Isoform C1 is stomach-specific. Isoform C2 is expressed at slightly higher levels in lung and stomach than in other tissues. {ECO:0000269PubMed:11006093}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005452	inorganic anion exchanger activity
GO:0008509	anion transmembrane transporter activity
GO:0015108	chloride transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006820	anion transport
GO:0006821	chloride transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Protein Structure and Domains

PDB ID

MGI:109351

InterPro

IPR001717 Anion exchange protein
IPR002978 Anion exchange protein 2
IPR003020 Bicarbonate transporter, eukaryotic
IPR011531 Bicarbonate transporter, C-terminal
IPR013769 Band 3 cytoplasmic domain
IPR016152 Phosphotransferase/anion transporter
IPR029028 Alpha/beta knot methyltransferases

PFAM

PF00955
PF07565

PRINTS

PR00165
PR01188
PR01231

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13808