InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ucma

Summary

InnateDB Protein

IDBP-250588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ucma

Protein Name

upper zone of growth plate and cartilage matrix associated

Synonyms

1110017I16Rik; AW121955; Grp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110662

InnateDB Gene

IDBG-134081 (Ucma)

Protein Structure

UniProt Annotation

Function

May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. {ECO:0000269PubMed:18156182}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:18156182, ECO:0000269PubMed:19819238}.Isoform 1: Secreted. Golgi apparatus.Isoform 3: Secreted. Golgi apparatus.Isoform 2: Cytoplasm, cytoskeleton {ECO:0000305}. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome.Isoform 4: Cytoplasm, cytoskeleton {ECO:0000305}. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome.

Disease Associations

Tissue Specificity

Predominantly expressed in resting chondrocytes. {ECO:0000269PubMed:18156182}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0045668

negative regulation of osteoblast differentiation

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0016235	aggresome
GO:0031012	extracellular matrix
GO:0048471	perinuclear region of cytoplasm