InnateDB Protein
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IDBP-250824.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dtx3l
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Protein Name
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deltex 3-like (Drosophila)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000110535
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InnateDB Gene
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IDBG-157467 (Dtx3l)
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Protein Structure
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Function |
Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation (By similarity). In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage in a PARP1- dependent manner. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
17 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2656973
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InterPro |
IPR001841
Zinc finger, RING-type
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PFAM |
PF13639
PF14634
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q3UIR3
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PhosphoSite |
PhosphoSite-Q3UIR3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
209200
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UniGene |
Mm.390852
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RefSeq |
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MGI ID |
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MGI Symbol |
Dtx3l
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK090152
AK146802
BC137694
CH466521
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GenPept |
AAI37695
BAC41115
BAE27443
EDK97899
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