Version 5.4
Mus musculus Protein: Parp9
Summary
InnateDB Protein IDBP-250837.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Parp9
Protein Name poly (ADP-ribose) polymerase family, member 9
Synonyms ARTD9; AW214463; Bagl; Bal; BC003281; PARP-9;
Species Mus musculus
Ensembl Protein ENSMUSP00000110528
InnateDB Gene IDBG-157549 (Parp9)
Protein Structure
UniProt Annotation
Function In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L (By similarity). Localizes at sites of DNA damage in a PARP1-dependent manner (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in the thymus and intestine. {ECO:0000269PubMed:18069692}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006302 double-strand break repair
GO:0060330 regulation of response to interferon-gamma
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1933117
InterPro IPR002589 Macro domain
IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
PFAM PF01661
PF00644
PRINTS
PIRSF
SMART SM00506
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CAS9
PhosphoSite PhosphoSite-Q8CAS9
TrEMBL H7BWY5
UniProt Splice Variant
Entrez Gene 80285
UniGene Mm.49074
RefSeq NP_084529
MGI ID
MGI Symbol Parp9
OMIM
CCDS CCDS37326
HPRD
IMGT
EMBL AC133464 AK037903 AK050032 BC003281 BC070466
GenPept AAH03281 AAH70466 BAC29897 BAC34040

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca