InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hs6st2

Summary

InnateDB Protein

IDBP-250864.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hs6st2

Protein Name

heparan sulfate 6-O-sulfotransferase 2

Synonyms

6OST2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110521

InnateDB Gene

IDBG-145065 (Hs6st2)

Protein Structure

UniProt Annotation

Function

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0017095	heparan sulfate 6-O-sulfotransferase activity

Biological Process

GO:0015015

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1354959

InterPro

IPR005331 Sulfotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF03567

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80UW0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

50786

UniGene

Mm.418288

RefSeq

NP_056634

MGI ID

MGI Symbol

Hs6st2

OMIM

CCDS

CCDS72379

HPRD

IMGT

EMBL

AB024565 AK052348 AK171680 AL671918 AL672057 AL672099 BC047151 BC063327

GenPept

AAH47151 AAH63327 BAA89247 BAC34950 BAE42608 CAM16284 CAM21295