InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eaf2

Summary

InnateDB Protein

IDBP-250943.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eaf2

Protein Name

ELL associated factor 2

Synonyms

AW048865; Festa; FESTA-L; FESTA-S; Traits; U19;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110473

InnateDB Gene

IDBG-158420 (Eaf2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional transactivator of ELL and ELL2 elongation activities (By similarity). Acts as a transcriptional transactivator of TCEA1 elongation activity. {ECO:0000250, ECO:0000269PubMed:12761297}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Note=Colocalizes with ELL to nuclear speckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in ovary, uterus, mammary glands, brain, spleen, liver, lung, thymus, kidney, skeletal muscle, skin and testis. Isoform 2 is expressed in kidney. {ECO:0000269PubMed:12761297, ECO:0000269PubMed:14517999}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0030308	negative regulation of cell growth
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0097193	intrinsic apoptotic signaling pathway