InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAMTS7

Summary

InnateDB Protein

IDBP-25105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS7

Protein Name

ADAM metallopeptidase with thrombospondin type 1 motif, 7

Synonyms

ADAM-TS 7; ADAM-TS7; ADAMTS-7;

Species

Homo sapiens

Ensembl Protein

ENSP00000373472

InnateDB Gene

IDBG-25099 (ADAMTS7)

Protein Structure

UniProt Annotation

Function

Metalloprotease that may play a role in the degradation of COMP. {ECO:0000269PubMed:16585064}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Also found associated with the external cell surface. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments. {ECO:0000269PubMed:15192113, ECO:0000269PubMed:16585064}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0032331	negative regulation of chondrocyte differentiation
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071773	cellular response to BMP stimulus

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0009986	cell surface
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR010294 ADAM-TS Spacer 1
IPR010909 PLAC
IPR013273 Peptidase M12B, ADAM-TS

PFAM

PF00090
PF01421
PF01562
PF05986
PF08686

PRINTS

PR01857

PIRSF

SMART

SM00209

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt